Mmmmm, good drugs

The not-so-secret about NyQuil is that it gives a cheap buzz. Here, from an article in Wired, is why:

Acetaminophen
One of the many wonder-pharmaceuticals that can be derived from coal tar, acetaminophen was used for nearly a century as a painkiller and fever reducer before anyone figured out how it worked. We now know that as the drug breaks down in the body, it turns into a cannabinoid: yes, stoners, the same type of compound that makes marijuana so irresistible. Doctors also once thought acetaminophen made users more talkative and outgoing. Current research suggests this idea was half-baked.

Dextromethorphan HBr
A cough suppressant. Well, actually, in the body it becomes dextrorphan, a cough suppressant, and levorphanol, a painkiller five times as powerful as morphine. Like PCP and ketamine, DXM is also an NMDA receptor antagonist, so the National Institute on Drug Abuse lists it as a "dissociative" drug. Twelve times the recommended dose of NyQuil leads to distorted perceptions of sight and sound and produces feelings of detachment — dissociation — from the environment and oneself. For people whose bodies are unusually slow at metabolizing the drug, even low doses of DXM trigger full-blown "Lucy in the Sky With Diamonds" psychedelic trips.

Doxylamine succinate
Officially, this ingredient is on the label as an antihistamine. But it is equally useful as a sleep aid, providing a nice, convenient one-two... Zzzz.

Wheeeeeeeeeeeeeeeeeeee...